CovidV2, new, Analysis, bibRecord, 000377

Genomic variance of the 2019-nCoV coronavirus.

Identifieur interne : 000377 ( new/Analysis ); précédent : 000376; suivant : 000378

Genomic variance of the 2019-nCoV coronavirus.

Auteurs : Carmine Ceraolo [Italie] ; Federico M. Giorgi [Italie]

Source :

Journal of medical virology [ 1096-9071 ] ; 2020.

RBID : pubmed:32027036

Descripteurs français

KwdFr :
- ARN viral (génétique), Animaux, Chiroptera (virologie), Génome viral, Humains, Infections à coronavirus, Modèles génétiques, Phylogénie, Pneumopathie virale, Protéome, Séquence d'acides aminés, Séquence nucléotidique, Variation génétique.
MESH :
- génétique : ARN viral.
- virologie : Chiroptera.
- Animaux, Génome viral, Humains, Infections à coronavirus, Modèles génétiques, Phylogénie, Pneumopathie virale, Protéome, Séquence d'acides aminés, Séquence nucléotidique, Variation génétique.

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Base Sequence, Betacoronavirus (classification), Betacoronavirus (genetics), Chiroptera (virology), Coronavirus Infections, Genetic Variation, Genome, Viral, Humans, Models, Genetic, Phylogeny, Pneumonia, Viral, Proteome, RNA, Viral (genetics).
MESH :
- chemical , genetics : RNA, Viral.
- chemical : Proteome.
- classification : Betacoronavirus.
- genetics : Betacoronavirus.
- virology : Chiroptera.
- Amino Acid Sequence, Animals, Base Sequence, Coronavirus Infections, Genetic Variation, Genome, Viral, Humans, Models, Genetic, Phylogeny, Pneumonia, Viral.

Abstract

There is a rising global concern for the recently emerged novel coronavirus (2019-nCoV). Full genomic sequences have been released by the worldwide scientific community in the last few weeks to understand the evolutionary origin and molecular characteristics of this virus. Taking advantage of all the genomic information currently available, we constructed a phylogenetic tree including also representatives of other coronaviridae, such as Bat coronavirus (BCoV) and severe acute respiratory syndrome. We confirm high sequence similarity (>99%) between all sequenced 2019-nCoVs genomes available, with the closest BCoV sequence sharing 96.2% sequence identity, confirming the notion of a zoonotic origin of 2019-nCoV. Despite the low heterogeneity of the 2019-nCoV genomes, we could identify at least two hypervariable genomic hotspots, one of which is responsible for a Serine/Leucine variation in the viral ORF8-encoded protein. Finally, we perform a full proteomic comparison with other coronaviridae, identifying key aminoacidic differences to be considered for antiviral strategies deriving from previous anti-coronavirus approaches.

DOI: 10.1002/jmv.25700
PubMed: 32027036

Affiliations:

Italie

Links to Exploration step

pubmed:32027036

Le document en format XML

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<front><div type="abstract" xml:lang="en">There is a rising global concern for the recently emerged novel coronavirus (2019-nCoV). Full genomic sequences have been released by the worldwide scientific community in the last few weeks to understand the evolutionary origin and molecular characteristics of this virus. Taking advantage of all the genomic information currently available, we constructed a phylogenetic tree including also representatives of other coronaviridae, such as Bat coronavirus (BCoV) and severe acute respiratory syndrome. We confirm high sequence similarity (>99%) between all sequenced 2019-nCoVs genomes available, with the closest BCoV sequence sharing 96.2% sequence identity, confirming the notion of a zoonotic origin of 2019-nCoV. Despite the low heterogeneity of the 2019-nCoV genomes, we could identify at least two hypervariable genomic hotspots, one of which is responsible for a Serine/Leucine variation in the viral ORF8-encoded protein. Finally, we perform a full proteomic comparison with other coronaviridae, identifying key aminoacidic differences to be considered for antiviral strategies deriving from previous anti-coronavirus approaches.</div>
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Genomic variance of the 2019-nCoV coronavirus.

Genomic variance of the 2019-nCoV coronavirus.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Covid (26 mars)
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